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Phenotypes Associated with This Genotype
Genotype
MGI:6317328
Allelic
Composition		 Mirc1tm1.1Tyj/Mirc1tm1.1Tyj
Pkd1tm2Som/Pkd1tm2Som
Tg(Cdh16-cre)91Igr/0
Genetic
Background		 involves: 129S4/SvJae * C57BL/6 * ICR
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mirc1tm1.1Tyj mutation (2 available); any Mirc1 mutation (7 available)
Pkd1tm2Som mutation (0 available); any Pkd1 mutation (151 available)
Tg(Cdh16-cre)91Igr mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:244067 )
• mice exhibit a median survival of 21 days which is a 50% improvement compared to single Pkd1 conditional mutants

renal/urinary system
decreased kidney cell proliferation ( J:244067 )
• the number of proliferating cyst epithelial cells is reduced by 78.7% compared to single Pkd1 conditional mutants
decreased kidney weight ( J:244067 )
• mice exhibit a 26.8% reduction in kidney-weight-to-body-weight ratio compared to single Pkd1 conditional mutants

cellular
decreased kidney cell proliferation ( J:244067 )
• the number of proliferating cyst epithelial cells is reduced by 78.7% compared to single Pkd1 conditional mutants

homeostasis/metabolism
decreased circulating creatinine level ( J:244067 )
• mice exhibit a 22% reduction in serum creatinine levels compared to single Pkd1 conditional mutants

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory