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Phenotypes Associated with This Genotype
Genotype
MGI:6315636
Allelic
Composition
Zdhhc9tm1Lex/Y
Genetic
Background
B6.129S5-Zdhhc9tm1Lex
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Zdhhc9tm1Lex mutation (2 available); any Zdhhc9 mutation (5 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• mice show impaired task acquisition in the Morris water maze indicating spatial learning deficits
• however, mice exhibit normal behavior in the probe trial indicating normal reference memory
• in the open field test, mice spend more time in the inner zone and subsequently less time near the walls during the habituation period but not during the test period indicating reduced anxiety levels
• in the elevated plus maze, mice spend more time exploring the more aversive open arms and the final third of the arms and less time exploring the closed arms
• mice exhibit reduced acoustic startle reactivity, beginning to show a startle response at decibel levels higher than 85 dB
• however, mice display a similar pattern of prepulse inhibition as wild-type mice, indicating normal sensorimotor gating and hearing ability

growth/size/body
• mice are lighter than wild-type mice

muscle
• in the hanging wire test, mice spend a shorter period of time hanging on the wire, indicative of hypotonia
• however, mice perform similar to wild-type mice on the rotarod test

nervous system
• mice have on average 30% reduction in the total volume of the corpus callosum
• however, no change in hippocampus size is seen

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
syndromic X-linked intellectual disability Raymond type DOID:0060824 OMIM:300799
J:268248


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/05/2019
MGI 6.14
The Jackson Laboratory