Phenotypes Associated with This Genotype

Genotype
MGI:6295910

• Allelic Composition: Cdk5rap3^{tm1c(EUCOMM)Hmgu}/Cdk5rap3^{tm1c(EUCOMM)Hmgu}; Tg(Foxa3-cre)1Khk/0
• Genetic Background: involves: 129S4/SvJaeSor * C57BL/6N * DBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:272566 )

• mice began to die after weaning

• however, supplementation with glucose after weaning rescues come mortality

liver/biliary system

abnormal hepatic cord morphology ( J:272566 )

• defective at 1 months with disorganized tubular structures extending away from portal tracts

• however, parenchyma organization at 0.5 months is normal

abnormal hepatocyte morphology ( J:272566 )

• smaller cell area at 1 month of age

• reduced hepatocyte maturation

small liver ( J:272566 )

decreased liver weight ( J:272566 )

liver hypoplasia ( J:272566 )

abnormal hepatocyte physiology ( J:272566 )

• hepatocytes exhibit perturbed endoplasmic reticulum homeostasis (increased ER stress and activated unfolded protein response) compared with control cells

homeostasis/metabolism

increased circulating bilirubin level ( J:272566 )

decreased fasting circulating glucose level ( J:272566 )

hypoglycemia ( J:272566 )

• at 1 month of age in fasted and fed mice

decreased circulating cholesterol level ( J:272566 )

decreased circulating triglyceride level ( J:272566 )

increased circulating alanine transaminase level ( J:272566 )

• however, serum aspartate transaminase levels are normal

growth/size/body

decreased body weight ( J:272566 )

• from 1 week of age