Phenotypes Associated with This Genotype

Genotype
MGI:6295907

• Allelic Composition: Cdk5rap3^{tm1b(EUCOMM)Hmgu}/Cdk5rap3^{tm1b(EUCOMM)Hmgu}
• Genetic Background: involves: C57BL/6N * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

lethality during fetal growth through weaning, complete penetrance ( J:272566 )

• mice die from E16.5 onward with none present at E18.5

liver/biliary system

abnormal cholangiocyte morphology ( J:272566 )

• impaired differentiation

abnormal hepatoblast differentiation ( J:272566 )

• at E16.5, fetal livers exhibit undifferentiated hepatocytes that lack polarity unlike in wild-type livers

small liver ( J:272566 )

• in the fetus

decreased liver weight ( J:272566 )

• at E16.5

liver hypoplasia ( J:272566 )

abnormal liver physiology ( J:272566 )

• increased apoptosis at E14.5 in cells

• however, hepatocytes exhibit normal survival

decreased hepatocyte proliferation ( J:272566 )

hematopoietic system

abnormal erythropoiesis ( J:272566 )

• impaired in fetuses

anemia ( J:272566 )

• profound in the fetus

increased nucleated erythrocyte cell number ( J:272566 )

• at E16.5 in the peripheral blood

decreased hematopoietic stem cell number ( J:272566 )

• at E14.5 in fetal livers

growth/size/body

fetal growth retardation ( J:272566 )

• at E14.5

cardiovascular system

hemorrhage ( J:272566 )

• at E14.5 onward

cellular

decreased hepatocyte proliferation ( J:272566 )

endocrine/exocrine glands

abnormal cholangiocyte morphology ( J:272566 )

• impaired differentiation