Phenotypes Associated with This Genotype

Genotype
MGI:6294908

• Allelic Composition: Cd79a^tm1(cre)Reth/Cd79a^tm1(cre)Reth; Mzb1^tm1.1Rug/Mzb1^tm1.1Rug
• Genetic Background: involves: 129S2/SvPas * BALB/c * C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

increased pro-B cell number ( J:211639 )

• increased percentage of B220+ CD43+ pro-B cells in bone marrow

increased late pro-B cell number ( J:211639 )

• increased percentage of B220+ CD19+ muHC- CD25- late pro-B cells in bone marrow

abnormal B cell number ( J:211639 )

• decrease in CD19+ B cells in splenic B cell compartment

• reduced frequency of peritoneal B cells

• reduced percentage of B220hi CD43- recirculating B cells in bone marrow

• reduced percentage of B220int CD43- pre-B cells in bone marrow

• reduced number of muHC+ cells in IL7+ bone marrow B cell cultures

• normal frequency of cells with intracellular muHC in IL7+ bone marrow B cell cultures

decreased pre-B cell number ( J:211639 )

• reduced CD25+ pre-B cell number in bone marrow

small spleen ( J:211639 )

immune system

increased pro-B cell number ( J:211639 )

• increased percentage of B220+ CD43+ pro-B cells in bone marrow

increased late pro-B cell number ( J:211639 )

• increased percentage of B220+ CD19+ muHC- CD25- late pro-B cells in bone marrow

abnormal B cell number ( J:211639 )

• decrease in CD19+ B cells in splenic B cell compartment

• reduced frequency of peritoneal B cells

• reduced percentage of B220hi CD43- recirculating B cells in bone marrow

• reduced percentage of B220int CD43- pre-B cells in bone marrow

• reduced number of muHC+ cells in IL7+ bone marrow B cell cultures

• normal frequency of cells with intracellular muHC in IL7+ bone marrow B cell cultures

decreased pre-B cell number ( J:211639 )

• reduced CD25+ pre-B cell number in bone marrow

small spleen ( J:211639 )