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Phenotypes Associated with This Genotype
Genotype
MGI:6287973
Allelic
Composition
Atg7tm1Tchi/Atg7tm1Tchi
Lyz2tm1(cre)Ifo/Lyz2+
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6NCrlj * CBA/JNCrlj
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atg7tm1Tchi mutation (1 available); any Atg7 mutation (30 available)
Lyz2tm1(cre)Ifo mutation (9 available); any Lyz2 mutation (15 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• mice appear normal at weaning but fail to gain weight

hematopoietic system
• increase in levels of circulating neutrophils
• increase in levels of circulating lymphocytes
• increase in levels of circulating monocytes
• IgG deposition in the glomeruli of kidneys
• macrophages exhibit an acute elevation of proinflammatory cytokines IL-1beta, IL-6, and IP-10, but not IL-10, in response to ingesting dying cells that is not seen in control macrophages
• however, neither bone marrow-derived macrophages nor peritoneal exudate macrophages from 52 week old mice show any defects in the engulfment of dying cells in vitro indicating normal phagocytic capacity

homeostasis/metabolism
• levels of CXCL1, CCL4 and CCL2 are increased in 52-week old mice

immune system
• increase in levels of circulating neutrophils
• increase in levels of circulating lymphocytes
• increase in levels of circulating monocytes
• IgG deposition in the glomeruli of kidneys
• macrophages exhibit an acute elevation of proinflammatory cytokines IL-1beta, IL-6, and IP-10, but not IL-10, in response to ingesting dying cells that is not seen in control macrophages
• however, neither bone marrow-derived macrophages nor peritoneal exudate macrophages from 52 week old mice show any defects in the engulfment of dying cells in vitro indicating normal phagocytic capacity
• levels of CXCL1, CCL4 and CCL2 are increased in 52-week old mice
• mice develop a systemic lupus erythematosus-like disease (SLE)
• increase in serum levels of a broad array of antibodies against autoantigens commonly associated with SLE
• kidneys from aged mice show endocapillary proliferative glomerulonephritis

renal/urinary system
• mice show indications of kidney damage and show increased functional markers of kidney injury
• IgG and complement C1q deposition in the glomeruli of kidneys
• kidneys from aged mice show endocapillary proliferative glomerulonephritis


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/10/2019
MGI 6.14
The Jackson Laboratory