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Phenotypes Associated with This Genotype
Genotype
MGI:6287219
Allelic
Composition
anx/anx
Tg(Tyro3-GFP)1Sapc/?
Tyro3m1/Tyro3m1
Genetic
Background
involves: C3HeB/FeJLe * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
anx mutation (1 available); any anx mutation (1 available)
Tg(Tyro3-GFP)1Sapc mutation (0 available)
Tyro3m1 mutation (4 available); any Tyro3 mutation (40 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• relative to anx homozygotes lacking the Tyro3 wildtype transgene, these mice show a partial rescue of phenotype with the body weight at 21 days of age 83.5% increased on average

mortality/aging
• wildtype mouse Tyro3 partially rescues the anx homozygous phenotype, with anx homozygotes still dying prematurely, but surviving past 35 days of age, having 83.58% of Npy+ soma retained in and properly distributed in the arcuate nucleus at 19 days of age, and showing no or only mild behavioural phentoypes of headweaving, ataxia, or tremors


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/18/2025
MGI 6.24
The Jackson Laboratory