Tyro3^m1
Spontaneous Allele Detail

Summary

• Symbol: Tyro3^m1
• Name: TYRO3 protein tyrosine kinase 3; mutation 1
• MGI ID: MGI:6197245
• Synonyms: Tyro3^R7Y
• Gene: Tyro3 Location: Chr2:119628221-119648585 bp, + strand Genetic Position: Chr2, 59.97 cM, cytoband F
• Alliance: Tyro3^m1 page

Mutation origin

• Strain of Origin: various

Mutation description

• Allele Type: Spontaneous (Not Applicable)
• Mutation: Single point mutation
• Mutation details: A single C-to-T transition in the signal sequence causes an arginine to tryptophan substitution at amino acid 13 (p.R13W). (J:241666)
• Inheritance: Recessive

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 4 strains available Cell Lines: 0 lines available
• Carrying any Tyro3 Mutation: 40 strains or lines available

References

• Original: J:241666 Kim DY, et al., The tyrosine kinase receptor Tyro3 enhances lifespan and neuropeptide Y (Npy) neuron survival in the mouse anorexia (anx) mutation. Dis Model Mech. 2017 May 01;10(5):581-595
• All: 1 reference(s)