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Phenotypes Associated with This Genotype
Genotype
MGI:6286197
Allelic
Composition		 Herc2Gt(AR0530)Wtsi/Herc2Gt(AR0530)Wtsi
Trp53tm1Tyj/Trp53tm1Tyj
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Herc2Gt(AR0530)Wtsi mutation (0 available); any Herc2 mutation (215 available)
Trp53tm1Tyj mutation (12 available); any Trp53 mutation (249 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality, complete penetrance ( J:252045 )
• loss of Trp53 expression does not rescue the embryonic lethality of Herc2Gt(AR0530)Wtsi homozygous mice

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory