Phenotypes for Dnmt3a Gt(ROSA)26Sor Npm1 Tg(Mx1-cre)1Cgn MGI:6286136 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Dnmt3a^tm1Trow/Dnmt3a⁺ Gt(ROSA)26Sor^{tm3(CAG-flpo/ERT2)Alj}/Gt(ROSA)26Sor⁺ Npm1^tm1Trow/Npm1⁺ Tg(Mx1-cre)1Cgn/0
Genetic Background	B6.Cg-Gt(ROSA)26Sor^{tm3(CAG-flpo/ERT2)Alj} Npm1^tm1Trow Dnmt3a^tm1Trow Tg(Mx1-cre)1Cgn

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dnmt3a^tm1Trow mutation (1 available); any Dnmt3a mutation (139 available)
Gt(ROSA)26Sor^{tm3(CAG-flpo/ERT2)Alj} mutation (2 available); any Gt(ROSA)26Sor mutation (1098 available)
Npm1^tm1Trow mutation (1 available); any Npm1 mutation (35 available)
Tg(Mx1-cre)1Cgn mutation (10 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

abnormal bone marrow cell physiology ( J:272803 )

• bone marrow cells transplanted into lethally irradiated recipients and treated with pIpC and tamoxifen results in death in a 100% of animals in a 440 day period

• in 33% of mice death is the result of myeloproliferative disorder (MPD)

• in 67% of mice death is the result of mixed myelodysplastic syndrome and myeloproliferative disorder (MDS/MPD)

• bone marrow cells from MDS/MPD or MPD primary transplants transplanted into sublethally irradiated secondary recipients results in 100% lethality due to acute myeloid leukemia (AML)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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