About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:6286134
Allelic
Composition		 Gt(ROSA)26Sortm3(CAG-flpo/ERT2)Alj/Gt(ROSA)26Sor+
Npm1tm1Trow/Npm1+
Genetic
Background		 B6.Cg-Gt(ROSA)26Sortm3(CAG-flpo/ERT2)Alj Npm1tm1Trow
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm3(CAG-flpo/ERT2)Alj mutation (2 available); any Gt(ROSA)26Sor mutation (1098 available)
Npm1tm1Trow mutation (1 available); any Npm1 mutation (35 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal bone marrow hematopoietic cell morphology ( J:272803 )
• increase in total number of colony forming units are found in whole bone marrow cells 4 months post-tamoxifen injection
increased granulocyte monocyte progenitor cell number ( J:272803 )
• expansion of granulocyte and granulocyte-macrophage colony types are found in whole bone marrow cells 4 months post-tamoxifen injection
decreased hematopoietic stem cell number ( J:272803 )
• decrease in frequency and total number of long term hematopoietic stem cells 4 months post-tamoxifen injection
• decrease in total number of short term hematopoietic stem cells 4 months post-tamoxifen injection
abnormal bone marrow cell physiology ( J:272803 )
• bone marrow cells transplanted into lethally irradiated recipients and treated with pIpC and tamoxifen results in death in a 29% of animals in a 440 day period due to myeloproliferative disorder

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory