About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:6285862
Allelic
Composition
Ucp2tm1Lowl/Ucp2tm1Lowl
Genetic
Background
B6.129S4-Ucp2tm1Lowl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ucp2tm1Lowl mutation (1 available); any Ucp2 mutation (36 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• males exhibited moribund signs (and were thus sacrificed) between 4 and 34 months of age
• females became moribund between 6 and 29 months of age

growth/size/body
• 8 of 142 mice carried pancreatic cysts, never observed in wild-type controls
• mice gained less body weight as they aged
• 19 of 142 mice that carried liver cysts also had kidney cysts of variable number and size
• incidence of kidney cysts was significantly higher than that in wild-type controls
• no kidney cysts were detected between 3 and 10 months of age
• 63 of 142 dissected moribund mice (>12 months of age) exhibited liver cysts of variable number and size
• all mice carrying kidney cysts or pancreatic cysts had liver cysts except one mouse
• no liver cysts were detected between 3 and 10 months of age

liver/biliary system
• 63 of 142 dissected moribund mice (>12 months of age) exhibited liver cysts of variable number and size
• all mice carrying kidney cysts or pancreatic cysts had liver cysts except one mouse
• no liver cysts were detected between 3 and 10 months of age

renal/urinary system
• 19 of 142 mice that carried liver cysts also had kidney cysts of variable number and size
• incidence of kidney cysts was significantly higher than that in wild-type controls
• no kidney cysts were detected between 3 and 10 months of age

endocrine/exocrine glands
• 8 of 142 mice carried pancreatic cysts, never observed in wild-type controls

homeostasis/metabolism
N
• mice with polycystic livers showed no significant differences in plasma alanine transaminase (ALT) and aspartate transaminase (AST) levels relative to non-diseased mice or wild-type controls

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
polycystic liver disease DOID:0050770 OMIM:174050
J:272325


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
01/12/2022
MGI 6.17
The Jackson Laboratory