Phenotypes Associated with This Genotype

Genotype
MGI:6282048

• Allelic Composition: Rab10^{tm1c(KOMP)Wtsi}/Rab10^{tm1c(KOMP)Wtsi}; Tg(Adipoq-cre)1Evdr/0
• Genetic Background: involves: C57BL/6J * C57BL/6N * FVB/NJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:249843 )

N • mice exhibit normal fasting plasma glycerol and NEFA levels and normal insulin-mediated suppression of plasma NEFA

increased circulating insulin level ( J:249843 )

• following glucose challenge

• however, levels after overnight fast are normal

increased hepatic glucose production ( J:249843 )

• lack of insulin suppression

insulin resistance ( J:249843 )

• when fed a low- or high-fat diet

adipose tissue

adipose tissue phenotype ( J:249843 )

N • mice exhibit normal visceral white adipose tissue with normal lipid droplet size

decreased adipocyte glucose uptake ( J:249843 )

• reduced insulin-stimulated glucose uptake

cellular

decreased adipocyte glucose uptake ( J:249843 )

• reduced insulin-stimulated glucose uptake