Phenotypes Associated with This Genotype

Genotype
MGI:6282006

• Allelic Composition: Del(15Rr38-Rr313939)7Fsp/Del(15Rr38-Rr313939)7Fsp
• Genetic Background: involves: C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

craniofacial

abnormal medial nasal prominence morphology ( J:212391 )

• reduced width of medionasal process in E11.5 embryos

• reduced number of mitotic cells in medionasal prominence in E11.5 embryos

• normal apoptosis

cleft upper lip ( J:212391 )

• in 4/121 E14-15 embryos

cleft palate ( J:212391 )

• in 4/121 E14-15 embryos

• no palatal clefts in pups

abnormal snout morphology ( J:212391 )

• abnormal nasal-frontal bone suture

short snout ( J:212391 )

• shorter nasal, frontal and parietal bone length at age 3 weeks

• normal parietal bone length at age 5 weeks

digestive/alimentary system

cleft palate ( J:212391 )

• in 4/121 E14-15 embryos

• no palatal clefts in pups

embryo

embryo phenotype ( J:212391 )

N • born at normal Mendelian ratios

growth/size/body

cleft upper lip ( J:212391 )

• in 4/121 E14-15 embryos

cleft palate ( J:212391 )

• in 4/121 E14-15 embryos

• no palatal clefts in pups

abnormal snout morphology ( J:212391 )

• abnormal nasal-frontal bone suture

short snout ( J:212391 )

• shorter nasal, frontal and parietal bone length at age 3 weeks

• normal parietal bone length at age 5 weeks

postnatal growth retardation ( J:212391 )

mortality/aging

preweaning lethality, incomplete penetrance ( J:212391 )

• some mice die before weaning