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Phenotypes Associated with This Genotype
Genotype
MGI:6280334
Allelic
Composition		 Crbntm1.1Ble/Crbntm1.1Ble
Csnk1a1tm1.1Ybn/Csnk1a1+
Tg(Mx1-cre)1Cgn/?
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Crbntm1.1Ble mutation (1 available); any Crbn mutation (33 available)
Csnk1a1tm1.1Ybn mutation (1 available); any Csnk1a1 mutation (38 available)
Tg(Mx1-cre)1Cgn mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
increased physiological sensitivity to xenobiotic ( J:267091 )
• hematopoietic stem and progenitor cells are more sensitive to lenalidomide in culture than cells from Csnk1a1tm1.1Ybn/+ Tg(Mx1-cre)1Cgn mice

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory