Phenotypes Associated with This Genotype

Genotype
MGI:6280314

• Allelic Composition: Spata22^repro42/Spata22^{tm1a(KOMP)Wtsi}
• Genetic Background: involves: C3H * C57BL/6N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

absent oocytes ( J:249350 )

♀ • adult ovaries show complete lack of oocytes

decreased male germ cell number ( J:249350 )

♂ • adult males exhibit an absence of certain spermatocytes, spermatids, and spermatozoa

azoospermia ( J:249350 )

♂

arrest of male meiosis ( J:249350 )

♂ • severe male germ cell depletion is caused by meiotic arrest

abnormal ovarian follicle morphology ( J:249350 )

♀ • adult ovaries contain degenerated follicles

small ovary ( J:249350 )

♀ • adult females exhibit smaller ovaries

ovary cyst ( J:249350 )

♀

small testis ( J:249350 )

♂ • adult males exhibit smaller testes

infertility ( J:249350 )

• both males and females are sterile but otherwise overtly normal

female infertility ( J:249350 )

♀

male infertility ( J:249350 )

♂

cellular

absent oocytes ( J:249350 )

♀ • adult ovaries show complete lack of oocytes

decreased male germ cell number ( J:249350 )

♂ • adult males exhibit an absence of certain spermatocytes, spermatids, and spermatozoa

azoospermia ( J:249350 )

♂

arrest of male meiosis ( J:249350 )

♂ • severe male germ cell depletion is caused by meiotic arrest

endocrine/exocrine glands

abnormal ovarian follicle morphology ( J:249350 )

♀ • adult ovaries contain degenerated follicles

small ovary ( J:249350 )

♀ • adult females exhibit smaller ovaries

ovary cyst ( J:249350 )

♀

small testis ( J:249350 )

♂ • adult males exhibit smaller testes

growth/size/body

ovary cyst ( J:249350 )

♀