Phenotypes Associated with This Genotype

Genotype
MGI:6279286

• Allelic Composition: Krit1^tm1Kwhi/Krit1^tm1Kwhi; Nfatc1^tm1.1(cre)Bz/Nfatc1⁺
• Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6NCrl

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:238897 )

• mice die prior to birth, with all embryos dead by E14.5-E15.5

cardiovascular system

abnormal heart morphology ( J:238897 )

• hearts show a reduction in space between the endocardium and myocardium that is occupied by cardiac jelly at E10.5 and E12.5

• in the myocardial trabeculae, the myocardium is wrapped tightly by endocardium unlike in wild-type mice where it is separated from the endocardium, indicating loss of endocardial-myocardial separation

abnormal myocardial trabeculae morphology ( J:238897 )

• E10.5 hearts exhibit smaller myocardial trabeculae

thin myocardium ( J:238897 )

• myocardium is thin at E10.5

decreased cardiac jelly amount ( J:238897 )

• area occupied by cardiac jelly in the trabeculae is decreased more than 65% at E10.5

• loss of matrix glycosaminoglycans in the heart, particularly surrounding the trabeculae at E10.5 and loss of intact versican indicates a reduction in cardiac jelly

dilated heart atrium ( J:238897 )

• atrial dilatation is seen at E12.5

dilated heart ventricle ( J:238897 )

• ventricular chamber dilatation is seen at E12.5

muscle

abnormal myocardial trabeculae morphology ( J:238897 )

• E10.5 hearts exhibit smaller myocardial trabeculae

thin myocardium ( J:238897 )

• myocardium is thin at E10.5