Phenotypes Associated with This Genotype

Genotype
MGI:6276334

• Allelic Composition: Tg(CAG-Ncoa6)87Hwl/0
• Genetic Background: involves: FVB

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

pulmonary vascular congestion ( J:80609 )

increased heart left atrium size ( J:80609 )

• hypertrophy of the left atrium

increased heart weight ( J:269856 )

• increase in heart-to-body weight ratios in 20 week old mice

cardiac hypertrophy ( J:80609 )

pericardial effusion ( J:269856 )

• frequent pericardial effusion

dilated cardiomyopathy ( J:269856 )

• hearts show features of dilated cardiomyopathy, including enlarged ventricular cavities with thin walls

decreased cardiac muscle contractility ( J:269856 )

• decrease in fractional shortening

congestive heart failure ( J:80609 )

muscle

dilated cardiomyopathy ( J:269856 )

• hearts show features of dilated cardiomyopathy, including enlarged ventricular cavities with thin walls

decreased cardiac muscle contractility ( J:269856 )

• decrease in fractional shortening

endocrine/exocrine glands

abnormal adrenal gland morphology ( J:80609 )

• adrenal gland redness

abnormal pituitary gland morphology ( J:80609 )

• pituitary gland redness and swelling

thymus atrophy ( J:80609 )

dilated gallbladder ( J:80609 )

• gall bladder hydrops

hematopoietic system

thymus atrophy ( J:80609 )

spleen atrophy ( J:80609 )

homeostasis/metabolism

pericardial effusion ( J:269856 )

• frequent pericardial effusion

abnormal atrial thrombosis ( J:80609 )

• mice exhibit atrial thrombosis

immune system

thymus atrophy ( J:80609 )

spleen atrophy ( J:80609 )

lung inflammation ( J:80609 )

liver/biliary system

dilated gallbladder ( J:80609 )

• gall bladder hydrops

hepatic steatosis ( J:80609 )

mortality/aging

premature death ( J:80609 , J:269856 )

• mice die within 2 months after birth with heart failure (J:80609)

• progenies of the founder die prematurely at 20 weeks of age (J:269856)

nervous system

abnormal pituitary gland morphology ( J:80609 )

• pituitary gland redness and swelling

renal/urinary system

renal hypoplasia ( J:80609 )

respiratory system

pulmonary vascular congestion ( J:80609 )

lung inflammation ( J:80609 )

pulmonary hypoplasia ( J:80609 )

vision/eye

cataract ( J:80609 )

• founder had bilateral cataract

microphthalmia ( J:80609 )

• founder had bilateral microphthalmia

anophthalmia ( J:80609 )

• progeny pups have no eyes

growth/size/body

increased heart weight ( J:269856 )

• increase in heart-to-body weight ratios in 20 week old mice

cardiac hypertrophy ( J:80609 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
dilated cardiomyopathy		DOID:12930	OMIM:PS115200	J:269856