Phenotypes Associated with This Genotype

Genotype
MGI:6275068

• Allelic Composition: Tg(ACTB-EGFP,-Kcnj8*)1Wco/0; Tg(Tek-cre)12Flv/0
• Genetic Background: involves: C3H * C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

abnormal blood vessel physiology ( J:134852 )

• mice exhibit impaired coronary function, showing elevated basal coronary perfusion pressure of isolated hearts at a constant flow rate

• mice show elevated release of the vasoconstrictor endothelin-1 in the coronary effluent from hearts

• treatment with the ATP-sensitive K⁺ channel blocker glibenclamide fails to produce a vasoconstrictive response as in controls

• mice pretreated with the endothelin-1 receptor antagonist bosentan show normal coronary perfusion pressure

• mice exhibit normal response to coronary vasospasm induced with ergonovine

growth/size/body

growth/size/body region phenotype ( J:134852 )

N • mice exhibit normal body weight and wet heart weight

mortality/aging

mortality/aging ( J:134852 )

N • mice exhibit a normal lifespan