Phenotypes Associated with This Genotype

Genotype
MGI:6274280

• Allelic Composition: Tg(Krt14-Rac1*G12V)#Mrnk/0
• Genetic Background: involves: CBA/CaJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

decreased body size ( J:237134 )

integument

skin hemorrhage ( J:237134 )

• lesions show hemorrhage (Auspitz sign) following scale removal

skin inflammation ( J:237134 )

• skin shows mixed inflammatory infiltrates

• lesional skin shows increased CD4+ and CD8+ lymphocytes, neutrophils, and dendritic cells

• stratum corneum shows increased CD3+ lymphocytes expressing IL17 and ROR-gamma and CD68+ cells, indicating Munros microabscesses

abnormal nail morphology ( J:237134 )

• nail changes range from ridging to marked thickening and onycholysis

abnormal nail matrix morphology ( J:237134 )

• mice show mild to severe nail changes, with nail matrix showing psoriasiform hyperplasia

abnormal skin morphology ( J:237134 )

• skin shows psoriasiform hyperplasia, hypogranulosis, mixed inflammatory infiltrates, dilated vessels in dermal papillae and parakeratosis

• however, mucosa does not exhibit proliferative or inflammatory changes

skin edema ( J:237134 )

• by 1 month of age, most mice develop edema of the tail and paws

parakeratosis ( J:237134 )

abnormal epidermis stratum granulosum morphology ( J:237134 )

• skin shows hypogranulosis

abnormal epidermis suprabasal layer morphology ( J:237134 )

• suprabasilar proliferation

reddish skin ( J:237134 )

• by 1 month of age, most mice develop erythema of the tail and paws

psoriasis ( J:237134 )

• mice develop erythematous, scaly skin lesions by day 7, that thicken by day 14 and are localized to ears, paws, tail and snout

• mutant pups develop psoriasis-like lesions in response to trauma created by mutant mothers biting the pups whiskers and snout hair

• mice typically exhibit wound-induced psoriasiform hyperplasia after tail snipping

• topical corticosteroid treatment improves skin lesions

• cyclosporin A treatment reduces epidermal thickness, proliferation and T cell infiltration

behavior/neurological

abnormal behavior ( J:237134 )

♀ • mutant mothers often bite their pups whiskers and snout hair, possibly to decrease nursing-related itching

cardiovascular system

skin hemorrhage ( J:237134 )

• lesions show hemorrhage (Auspitz sign) following scale removal

homeostasis/metabolism

abnormal circulating interleukin level ( J:237134 )

• 3 week old mice show a 7-fold and 2.5-fold increases in psoriasis-associated cytokine IL-22 and IL-23 in sera

skin edema ( J:237134 )

• by 1 month of age, most mice develop edema of the tail and paws

immune system

abnormal circulating interleukin level ( J:237134 )

• 3 week old mice show a 7-fold and 2.5-fold increases in psoriasis-associated cytokine IL-22 and IL-23 in sera

joint inflammation ( J:237134 )

• mutants with joint involvement show neutrophilic infiltrates near joint spaces

skin inflammation ( J:237134 )

• skin shows mixed inflammatory infiltrates

• lesional skin shows increased CD4+ and CD8+ lymphocytes, neutrophils, and dendritic cells

• stratum corneum shows increased CD3+ lymphocytes expressing IL17 and ROR-gamma and CD68+ cells, indicating Munros microabscesses

skeleton

joint inflammation ( J:237134 )

• mutants with joint involvement show neutrophilic infiltrates near joint spaces

abnormal joint morphology ( J:237134 )

• about 50% of mice show a mutilating arthropathy, with bony paw deformations and/or partial tail autoamputation

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
psoriasis		DOID:8893	OMIM:PS177900	J:237134