Phenotypes Associated with This Genotype

Genotype
MGI:6273838

• Allelic Composition: Hprt1^{tm1(CAG-Gys1*)Jjg}/?; Myl1^tm1(cre)Sjb/Myl1⁺
• Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

impaired exercise endurance ( J:244440 )

• in spite of increased skeletal muscle glycogen level, mice reach exhaustion earlier than wild-type controls in a treadmill endurance test

decreased aerobic running capacity ( J:244440 )

• mice cover a shorter distance than wild-type controls in a treadmill endurance test

increased skeletal muscle glycogen level ( J:244440 )

• under resting conditions, adult mice show a 7-fold increase in skeletal muscle glycogen level relative to wild-type controls

abnormal response to exercise ( J:244440 )

• at the point of exhaustion following treadmill exercise, mice show a greater reduction of glycogen content in skeletal muscle than wild-type controls

muscle

increased skeletal muscle glycogen level ( J:244440 )

• under resting conditions, adult mice show a 7-fold increase in skeletal muscle glycogen level relative to wild-type controls

behavior/neurological

impaired exercise endurance ( J:244440 )

• in spite of increased skeletal muscle glycogen level, mice reach exhaustion earlier than wild-type controls in a treadmill endurance test

decreased aerobic running capacity ( J:244440 )

• mice cover a shorter distance than wild-type controls in a treadmill endurance test

cellular

abnormal cellular respiration ( J:244440 )

• adult soleus muscle exhibits lower oxygen consumption affecting all mitochondrial states relative to wild-type muscle