Phenotypes for Smcr8 Tlr3 Tlr7 Tlr9 MGI:6272653 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Smcr8^em1Btlr/Smcr8^em1Btlr Tlr3^tm1Flv/Tlr3^tm1Flv Tlr7^tm1Aki/Tlr7^tm1Aki Tlr9^tm1Aki/Tlr9^tm1Aki
Genetic Background	involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Smcr8^em1Btlr mutation (0 available); any Smcr8 mutation (40 available)
Tlr3^tm1Flv mutation (6 available); any Tlr3 mutation (71 available)
Tlr7^tm1Aki mutation (3 available); any Tlr7 mutation (21 available)
Tlr9^tm1Aki mutation (7 available); any Tlr9 mutation (66 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:268243 )

N	• unlike in Smcr8^em1Btlr homozygotes, spleen and lymph nodes are restored to normal as well as is the hyperactivation of T cells and increased circulating IL12p40 levels

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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