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Phenotypes Associated with This Genotype
Genotype
MGI:6272035
Allelic
Composition
TnfBpsm1/Tnf+
Genetic
Background
involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
TnfBpsm1 mutation (0 available); any Tnf mutation (35 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• mice gradually lose grasping strength
• progressive paralysis of the hindlimbs

cardiovascular system
• Background Sensitivity: aortic aneurism is much less pronounced on the C57BL/6 background than in mice on a BALB/c background
• aortic and mitral valve inflammation

homeostasis/metabolism
• increase in circulating TNF levels
• however, circulating levels of IL1 beta, IL6, IL18, and IL23 are normal

immune system
• aortic and mitral valve inflammation
• increase in circulating TNF levels
• however, circulating levels of IL1 beta, IL6, IL18, and IL23 are normal
• mice exhibit a severe symmetrical, erosive chronic polyarthritis that predominately affects the peripheral joints and less severe damage in central joints
• joints show extensive pannus invasion, bone destruction and cartilage erosion
• pannus tissue is mostly F4.80 cells and most affected joints are devoid of lymphocytes and neutrophils
• bone erosion is maximal in joints with the highest load factor
• lethally irradiated wild-type mice transplanted with mutant bone marrow develop arthritis within 5 months
• 5 week old mutant mice transplanted with wild-type bone marrow do not develop arthritis over the following 5 months
• however, mice do not contain IgM or IgG rheumatoid factors and no inflammation is seen in the skin, liver, blood vessels, eyes or gut and no evidence for cartilage or bone repair is seen

limbs/digits/tail
• limbs are deformed and mice gradually show forelimbs that become angled at the wrist level and hind-limb digits become immobile

mortality/aging
N
• Background Sensitivity: no mice on the C57BL/6 background die up to 200 days of age while sudden death is seen on the BALB/c background

skeleton
• mice exhibit a severe symmetrical, erosive chronic polyarthritis that predominately affects the peripheral joints and less severe damage in central joints
• joints show extensive pannus invasion, bone destruction and cartilage erosion
• pannus tissue is mostly F4.80 cells and most affected joints are devoid of lymphocytes and neutrophils
• bone erosion is maximal in joints with the highest load factor
• lethally irradiated wild-type mice transplanted with mutant bone marrow develop arthritis within 5 months
• 5 week old mutant mice transplanted with wild-type bone marrow do not develop arthritis over the following 5 months
• however, mice do not contain IgM or IgG rheumatoid factors and no inflammation is seen in the skin, liver, blood vessels, eyes or gut and no evidence for cartilage or bone repair is seen
• the 13th (floating) ribs enter the neural canal instead of being attached to the centrum
• hunchback is due to erosion of the T10-T13 thoracic vertebrae
• abnormal curvature of the spine at the level of the rib cage
• a pronounced hunchback is seen at around 7 months of age associated with the progressive paralysis of hind limbs
• hindpaws of 100 day old mice are luxated at the level of the ankle

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
rheumatoid arthritis DOID:7148 OMIM:180300
J:226052


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/16/2019
MGI 6.13
The Jackson Laboratory