Phenotypes Associated with This Genotype

Genotype
MGI:6269406

• Allelic Composition: Ednrb^tm1Nrd/Ednrb^tm1Nrd; Tg(Dct-lacZ)#Ove/0; Tg(Tyr-cre/ERT2)13Bos/0
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

pigmentation

abnormal epidermal melanocyte morphology ( J:231435 )

• following TAM treatment immediately after wounding at 8 weeks of age, mice show a significantly reduced number of epidermal melanocytes in the wound area both at day 0 and day 8 after re- epithelialization relative to control mice

• however, no signs of apoptosis are observed, suggesting normal survival of epidermal melanocytes after wounding

decreased melanocyte number ( J:231435 )

• following initial TAM treatment during 2nd anagen, the number of Dct-LacZ+ melanocyte stem cells (McSCs) in unpigmented hair follicles is significantly lower than that in control mice by the 2nd telogen; most unpigmented hair follicles completely lack McSCs by the 3rd and 4th telogen

integument

abnormal epidermal melanocyte morphology ( J:231435 )

• following TAM treatment immediately after wounding at 8 weeks of age, mice show a significantly reduced number of epidermal melanocytes in the wound area both at day 0 and day 8 after re- epithelialization relative to control mice

• however, no signs of apoptosis are observed, suggesting normal survival of epidermal melanocytes after wounding