Phenotypes Associated with This Genotype

Genotype
MGI:6267347

• Allelic Composition: Chaf1b^{tm2c(EUCOMM)Hmgu}/Chaf1b⁺; Tg(Mx1-cre)1Cgn/0
• Genetic Background: involves: C57BL/6J * C57BL/6N * CBA/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

abnormal bone marrow cell morphology/development ( J:266848 )

• bone marrow cells from pIpC-treated mice fail to form fewer colonies in culture compared with control cell

decreased bone marrow cell number ( J:266848 )

• modest reduction in pIpC-treated mice

decreased hematopoietic stem cell number ( J:266848 )

• in the bone marrow cells from pIpC-treated mice with an increase in the percentage of LK cells, decrease in LSK cells and increased proportion of short-term SLAM+ cells

abnormal bone marrow cell physiology ( J:266848 )

• modest increase in apoptosis in the bone marrow of pIpC-treated mice

cellular

increased apoptosis ( J:266848 )

• modest increase in apoptosis in the bone marrow of pIpC-treated mice