Phenotypes Associated with This Genotype

Genotype
MGI:6267346

• Allelic Composition: Chaf1b^{tm2c(EUCOMM)Hmgu}/Chaf1b^{tm2c(EUCOMM)Hmgu}; Tg(Mx1-cre)1Cgn/0
• Genetic Background: involves: C57BL/6J * C57BL/6N * CBA/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:266848 )

• pIpC-treated mice die within two weeks of treatment

hematopoietic system

abnormal bone marrow cell morphology/development ( J:266848 )

• bone marrow cells from pIpC-treated mice fail to form colonies in culture

decreased bone marrow cell number ( J:266848 )

• in pIpC-treated mice

decreased hematopoietic cell number ( J:266848 )

• in the bone marrow of pIpC-treated mice

decreased hematopoietic stem cell number ( J:266848 )

• in the bone marrow cells from pIpC-treated mice

pancytopenia ( J:266848 )

• in pIpC-treated mice

abnormal bone marrow cell physiology ( J:266848 )

• increased apoptosis in the bone marrow of pIpC-treated mice

• bone marrow cells from pIpC-treated mice exhibit impaired hematopoietic reconstitution compared with with cells from control mice

cellular

increased apoptosis ( J:266848 )

• increased apoptosis in the bone marrow of pIpC-treated mice