Phenotypes Associated with This Genotype

Genotype
MGI:6263942

• Allelic Composition: Zwint^em1(IMPC)J/Zwint^em1(IMPC)J
• Genetic Background: C57BL/6NJ-Zwint^em1(IMPC)J/J

Data Sources

IMPC Data for Zwint

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Zwint^em1(IMPC)J/Zwint^em1(IMPC)J mice exhibit embryonic lethality, with embryos recovered at E3.5 as blastocysts but no embryos at E7.5. Blastocysts grown in vitro hatch from the zona pellucia but the inner cell mass/epiblast cells form a smaller outgrowth colony.

embryo

small embryonic epiblast ( J:279207 )

• epiblast cells form a smaller than normal outgrowth colony after 3 days in culture

abnormal inner cell mass morphology ( J:279207 )

• inner cell mass (ICM) cells form a smaller than normal outgrowth colony after 3 days in culture

• however, blastocysts hatch from the zona pellucida with apparent trophectoderm and primitive endoderm cells

mortality/aging

embryonic lethality prior to organogenesis ( J:211773 )

IMPC - JAX

preweaning lethality, complete penetrance ( J:211773 )

IMPC - JAX

embryonic lethality prior to organogenesis, complete penetrance ( J:279207 )

• normal looking blastocysts are present at E3.5 (36% versus expected 25%, n=11); no embryos are recovered at E7.5 with an excess number of resorption sites