Phenotypes Associated with This Genotype

Genotype
MGI:6263845

• Allelic Composition: Utp4^em1(IMPC)J/Utp4^em1(IMPC)J
• Genetic Background: C57BL/6NJ-Utp4^em1(IMPC)J/Mmjax

Data Sources

IMPC Data for Utp4

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Utp4^em1(IMPC)J/Utp4^em1(IMPC)J mice exhibit embryonic lethality, with embryos recovered at E3.5 as dying morulae but not at E7.5. Mutants fail to hatch from the zona pellucida and are dead after 3 days in culture.

embryo

failure of blastocyst to hatch from the zona pellucida ( J:279207 )

• in vitro outgrowth assays show that embryos fail to hatch from the zona pellucida and are dead after 3 days in culture

abnormal morula morphology ( J:279207 )

• embryos recovered at E3.5 appear as dying morulae

mortality/aging

embryonic lethality prior to organogenesis ( J:211773 )

IMPC - JAX

preweaning lethality, complete penetrance ( J:211773 )

IMPC - JAX

embryonic lethality prior to organogenesis, complete penetrance ( J:279207 )

• homozygous embryos are recovered at E3.5 (9% versus expected 25%, n=35) and appear as dying morulae; no embryos are recovered at E7.5

• however, excess resorption sites suggest that embryos elicit a decidual response in vivo