Phenotypes Associated with This Genotype

Genotype
MGI:6262049

• Allelic Composition: Ccdc59^em1(IMPC)J/Ccdc59^em1(IMPC)J
• Genetic Background: C57BL/6NJ-Ccdc59^em1(IMPC)J/J

Data Sources

IMPC Data for Ccdc59

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Ccdc59^em1(IMPC)J/Ccdc59^em1(IMPC)J mice exhibit embryonic lethality, with no embryos seen at E9.5 and only a small percentage of necrotic embryos at E7.5. Embryos fail to gastrulate, are smaller, with absent egg cylinders, head folds, primitive node, and primitive streak formation at E7.5.

embryo

failure to gastrulate ( J:279207 )

• no morphological hallmarks typical of gastrulating embryos are observed at E7.5

embryonic growth arrest ( J:279207 )

• embryos arrest prior to gastrulation

decreased embryo size ( J:279207 )

• embryos are much smaller than controls at E7.5

absent egg cylinders ( J:279207 )

• no rudimentary egg cylinder is present at E7.5

absent head fold ( J:279207 )

• no head folds are present at E7.5

absent primitive node ( J:279207 )

• no embryonic node is present at E7.5

failure of primitive streak formation ( J:279207 )

• no morphological evidence of primitive streak formation is observed at E7.5

embryo tissue necrosis ( J:279207 )

• embryos appear as a necrotic mass of cells at E7.5

growth/size/body

decreased embryo size ( J:279207 )

• embryos are much smaller than controls at E7.5

mortality/aging

embryonic lethality prior to organogenesis ( J:211773 )

IMPC - JAX

preweaning lethality, complete penetrance ( J:211773 )

IMPC - JAX

embryonic lethality between implantation and placentation, complete penetrance ( J:279207 )

• only 6% of necrotic homozygous embryos are recovered at E7.5; no homozygous embryos are recovered at E9.5