Phenotypes Associated with This Genotype

Genotype
MGI:6261958

• Allelic Composition: Cdin1^em1(IMPC)J/Cdin1^em1(IMPC)J
• Genetic Background: C57BL/6NJ-Cdin1^em1(IMPC)J/J

Data Sources

IMPC Data for Cdin1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Cdin1^em1(IMPC)J/Cdin1^em1(IMPC)J mice exhibit embryonic lethality, with embryos recovered at E3.5 as blastocysts but not at E7.5. Blastocysts hatch from the zona pellucida and form typical outgrowth colonies.

mortality/aging

embryonic lethality prior to organogenesis ( J:211773 )

IMPC - JAX

preweaning lethality, complete penetrance ( J:211773 )

IMPC - JAX

embryonic lethality between implantation and somite formation, complete penetrance ( J:279207 )

• although normal looking blastocysts are present in relatively normal Mendelian ratios at E3.5 (18% versus expected 25%, n=28), no homozygous embryos or excess resorption sites are observed at E7.5

• in vitro, blastocysts hatch from the zona pellucida and form typical outgrowth colonies after 3 days in culture