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Phenotypes Associated with This Genotype
Genotype
MGI:6260013
Allelic
Composition		 Rps6tm1Gtho/Rps6+
Trp53tm1Tyj/Trp53+
Tg(KRT5-cre)5132Jlj/0
Genetic
Background		 involves: 129 * C57BL/6J * DBA/2J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rps6tm1Gtho mutation (3 available); any Rps6 mutation (15 available)
Tg(KRT5-cre)5132Jlj mutation (1 available)
Trp53tm1Tyj mutation (12 available); any Trp53 mutation (249 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
pigmentation
increased foot pad pigmentation ( J:139244 )
• mice exhibit an intermediate footpad pigmentation phenotype and reduced Kitl mRNA levels in the footpad epidermis at P30, indicating partial amelioration of the dark skin observed in mice that are only heterozygous for Rps6tm1Gtho and hemizygous for Tg(KRT5-cre)5132Jlj

integument
increased foot pad pigmentation ( J:139244 )
• mice exhibit an intermediate footpad pigmentation phenotype and reduced Kitl mRNA levels in the footpad epidermis at P30, indicating partial amelioration of the dark skin observed in mice that are only heterozygous for Rps6tm1Gtho and hemizygous for Tg(KRT5-cre)5132Jlj

limbs/digits/tail
increased foot pad pigmentation ( J:139244 )
• mice exhibit an intermediate footpad pigmentation phenotype and reduced Kitl mRNA levels in the footpad epidermis at P30, indicating partial amelioration of the dark skin observed in mice that are only heterozygous for Rps6tm1Gtho and hemizygous for Tg(KRT5-cre)5132Jlj

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory