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Phenotypes Associated with This Genotype
Genotype
MGI:6259616
Allelic
Composition		 Igs2tm1(CAG-mt-Keima)Fink/Igs2+
Lamp2tm1Psa/Lamp2tm1Psa
Genetic
Background		 involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igs2tm1(CAG-mt-Keima)Fink mutation (0 available); any Igs2 mutation (72 available)
Lamp2tm1Psa mutation (0 available); any Lamp2 mutation (13 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
abnormal myocardial fiber physiology ( J:253728 )
• cardiomyocytes from 20 week old mice exhibit impaired delivery of damaged mitochondria to the lysosomes for degradation and increased accumulation of damaged mitochondria in the cytoplasm and within autophagic vacuoles

cellular
abnormal mitophagy ( J:253728 )
• cardiomyocytes from 20 week old mice exhibit impaired delivery of damaged mitochondria to the lysosomes for degradation and increased accumulation of damaged mitochondria in the cytoplasm and within autophagic vacuoles

homeostasis/metabolism
abnormal mitophagy ( J:253728 )
• cardiomyocytes from 20 week old mice exhibit impaired delivery of damaged mitochondria to the lysosomes for degradation and increased accumulation of damaged mitochondria in the cytoplasm and within autophagic vacuoles

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory