Phenotypes Associated with This Genotype

Genotype
MGI:6259602

• Allelic Composition: Trim67^tm1.2Slgu/Trim67^tm1.2Slgu
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

nervous system phenotype ( J:266702 )

N • size of the anterior commissure and thickness of the cortex are similar to controls

decreased brain weight ( J:266702 )

• postfixation weight is about 10% less than littermate controls

decreased hippocampal commissure size ( J:266702 )

• thinner

decreased brain internal capsule size ( J:266702 )

• decreased cross-sectional area

abnormal forebrain morphology ( J:266702 )

• decreased cross-sectional area of the stria terminalis

small lateral ventricles ( J:266702 )

decreased corpus callosum size ( J:266702 )

• decreased thickness

abnormal dorsal striatum morphology ( J:266702 )

decreased stria medullaris size ( J:266702 )

• decreased cross-sectional area

small thalamus ( J:266702 )

decreased amygdala size ( J:266702 )

abnormal hippocampus morphology ( J:266702 )

• anterior aspect of the hippocampal gray matter begins ~100 um posterior in homozygous mice compared to wild-type littermate controls

small hippocampus ( J:266702 )

decreased prepulse inhibition ( J:266702 )

• deficits in mice at 17-19 weeks of age but not at 10-11 weeks of age

behavior/neurological

abnormal cognition ( J:266702 )

impaired spatial learning ( J:266702 )

• in the reversal learning test in a Morris water maze mice swim more slowly and take longer to find the hidden platform

• after 9 days of testing mice fail to reach the criterion for learning

abnormal spatial reference memory ( J:266702 )

• in a probe trial in a Morris water maze mice fail to spend more time in the quadrant that previously held the platform

cognitive inflexibility ( J:266702 )

• mice show significant impairment in the ability to learn the new location of a platform during the reversal phase of a Morris water maze assay

abnormal response to social novelty ( J:266702 )

• fail to show a preference for a novel stranger mouse over a known mouse

decreased startle reflex ( J:266702 )

• mild decrease in mice at 17-19 weeks of age but not at 10-11 weeks of age

impaired coordination ( J:266702 )

• fall off a rotating barrel sooner than controls but do show improved performance with training

decreased grip strength ( J:266702 )

• significantly shorter maximum and average hang impulse in a four-paw rolling-wire hang assay suggesting a decrease in muscle tone