Phenotypes Associated with This Genotype

Genotype
MGI:6259522

• Allelic Composition: Nae1^{tm1c(EUCOMM)Wtsi}/Nae1^{tm1c(EUCOMM)Wtsi}; Tg(Camk2a-cre/ERT2)2Gsc/0; Tg(Thy1-EGFP)MJrs/0
• Genetic Background: involves: C57BL/6J * C57BL/6N * CBA * FVB/N * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:262411 )

N • mice exhibit normal locomotion, sociability, fear conditioning and anxiety related behaviors

impaired long-term object recognition memory ( J:262411 )

• impaired in tamoxifen-treated mice

impaired short-term object recognition memory ( J:262411 )

• impaired in tamoxifen-treated mice

abnormal spatial working memory ( J:262411 )

• tamoxifen-treated mice exhibit impaired performance in a water-cross maze and Y-maze

nervous system

abnormal dendritic spine morphology ( J:262411 )

• reduced size in the cortical and hippocampal pyramidal neurons of tamoxifen-treated mice

• however, general neuron morphology is normal

decreased dendritic spine density ( J:262411 )

• in the cortical and hippocampal pyramidal neurons of tamoxifen-treated mice

abnormal CNS synaptic transmission ( J:262411 )

• reduced in tamoxifen-treated mice

• however, excitability is normal