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Phenotypes Associated with This Genotype
Genotype
MGI:6257845
Allelic
Composition
Tg(Alb-SND1)3aDsar/0
Genetic
Background
involves: C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Alb-SND1)3aDsar mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• at 32 weeks after N-nitrosodiethylamine (DEN) injection, mice developaggressive hepatocellular carcinoma, with tumorigenesis affecting the entire liver, with elevated serum aspartate transaminase, alanine transaminase, and total protein levels compared to wild-type mice which have either no nodules or very small nodules
• at 1 year of age, 42% of mice develop hepatic nodules that are hepatocellular carcinoma, with loss of hepatic architecture
• maker analysis indicates the expansion of tumor-initiation cells in livers

liver/biliary system
• mice exhibit chronic inflammation as indicated by increased expression of IL6 and TNFalpha and increased infiltration of macrophages in tumor bearing livers
• at 1 year of age, 42% of mice develop hepatic nodules that are hepatocellular carcinoma, with loss of hepatic architecture
• maker analysis indicates the expansion of tumor-initiation cells in livers
• in a sphere formation assay, hepatocytes form robust spheres that gradually increase in size and number, indicating an expansion of tumor-initiation cells compared to wild-type hepatocytes which form small spheres
• hepatocytes show invasion through Matrigel that is not seen in wild-type hepatocytes

immune system
• mice exhibit chronic inflammation as indicated by increased expression of IL6 and TNFalpha and increased infiltration of macrophages in tumor bearing livers

homeostasis/metabolism
• at 32 weeks after N-nitrosodiethylamine (DEN) injection, mice developaggressive hepatocellular carcinoma, with tumorigenesis affecting the entire liver, with elevated serum aspartate transaminase, alanine transaminase, and total protein levels compared to wild-type mice which have either no nodules or very small nodules

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
hepatocellular carcinoma DOID:684 OMIM:114550
J:242582


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/05/2019
MGI 6.14
The Jackson Laboratory