Analysis Tools
behavior/neurological
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• mice show improved performance day by day in both the escape latency and distance during the hidden platform trails of the Morris water maze compared to single Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas expressing mice
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homeostasis/metabolism
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• mice show lower levels of both soluble and insoluble amyloid beta 42 in the brain than in single Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas expressing mice
• however, expression of the precursor APP remains unaffected
• mice show a reduction of amyloid plaques in the cortex and a trend of reduction in the hippocampus
• short-term treatment of mice with SBI-0206965, an autophagy inhibitor blocking the kinase activity of an essential upstream kinase ULK1, abolishes the reduction in brain amyloid beta 42 levels
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nervous system
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• mice show lower levels of both soluble and insoluble amyloid beta 42 in the brain than in single Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas expressing mice
• however, expression of the precursor APP remains unaffected
• mice show a reduction of amyloid plaques in the cortex and a trend of reduction in the hippocampus
• short-term treatment of mice with SBI-0206965, an autophagy inhibitor blocking the kinase activity of an essential upstream kinase ULK1, abolishes the reduction in brain amyloid beta 42 levels
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