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Phenotypes Associated with This Genotype
Genotype
MGI:6256968
Allelic
Composition		 Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo/Gt(ROSA)26Sor+
Pikfyvetm2.1Tssk/Pikfyvetm2.1Tssk
Tg(Tyr-cre/ERT2)13Bos/0
Genetic
Background		 involves: C57BL/6 * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo mutation (10 available); any Gt(ROSA)26Sor mutation (1098 available)
Pikfyvetm2.1Tssk mutation (0 available); any Pikfyve mutation (114 available)
Tg(Tyr-cre/ERT2)13Bos mutation (12 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Early greying in Pikfyvetm2.1Tssk/Pikfyvetm2.1Tssk Tg(Tyr-cre/ERT2)13Bos/0 Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo/Gt(ROSA)26Sor+ mice

pigmentation
diluted coat color ( J:262141 )
• after 4-OHT treatment (P21-P50) mice exhibit an early greying phenotype at P50
• however, GFP+ cells associated with hair follicles are present at P100, indicating that melanocyte survival is not significantly affected

integument
diluted coat color ( J:262141 )
• after 4-OHT treatment (P21-P50) mice exhibit an early greying phenotype at P50
• however, GFP+ cells associated with hair follicles are present at P100, indicating that melanocyte survival is not significantly affected

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory