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Phenotypes Associated with This Genotype
Genotype
MGI:6241535
Allelic
Composition		 Resttm1.1Yasu/Resttm1.1Yasu
H2az2Tg(Wnt1-cre)11Rth/H2az2+
Tg(Dct-lacZ)A12Jkn/0
Genetic
Background		 involves: 129S4/SvJae * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2az2Tg(Wnt1-cre)11Rth mutation (2 available); any H2az2 mutation (25 available)
Resttm1.1Yasu mutation (1 available); any Rest mutation (92 available)
Tg(Dct-lacZ)A12Jkn mutation (5 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
embryo
abnormal melanoblast morphology ( J:230341 )
• at E12.5 and E14.5, the number of Dct-LacZ+ cells in the belly region is significantly lower than that in control mice
• at E17.5, the distribution pattern of LacZ+ cells is altered in skin from the abdomen, but not from the back or head

nervous system
abnormal melanoblast morphology ( J:230341 )
• at E12.5 and E14.5, the number of Dct-LacZ+ cells in the belly region is significantly lower than that in control mice
• at E17.5, the distribution pattern of LacZ+ cells is altered in skin from the abdomen, but not from the back or head

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory