Phenotypes Associated with This Genotype

Genotype
MGI:6241534

• Allelic Composition: Gt(ROSA)26Sor^tm1Sor/Gt(ROSA)26Sor⁺; Rest^tm1.1Yasu/Rest^tm1.1Yasu; H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺
• Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6J * CBA/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

embryo

abnormal melanoblast morphology ( J:230341 )

• at E14.5, the number of LacZ+ neural crest cell-derived cells in the skin is lower in both the head and belly regions than that in NCC-specific heterozygous knockout littermates carrying only one Rest^tm1.1Yasu allele

nervous system

abnormal melanoblast morphology ( J:230341 )

• at E14.5, the number of LacZ+ neural crest cell-derived cells in the skin is lower in both the head and belly regions than that in NCC-specific heterozygous knockout littermates carrying only one Rest^tm1.1Yasu allele