Phenotypes Associated with This Genotype

Genotype
MGI:6241489

• Allelic Composition: Rest^tm1.1Yasu/Rest⁺; H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺
• Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6J * CBA/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

mortality/aging ( J:230341 )

N • mice are viable and survive to adulthood

pigmentation

belly spot ( J:230341 )

• ~60% of mice exhibit a white belly spot of variable size ranging from a few white hairs to a white spot that is ~1 cm in diameter; in contrast, only ~15% of control mice carrying the transgene alone form an extremely small, striated white-haired area on the belly

integument

belly spot ( J:230341 )

• ~60% of mice exhibit a white belly spot of variable size ranging from a few white hairs to a white spot that is ~1 cm in diameter; in contrast, only ~15% of control mice carrying the transgene alone form an extremely small, striated white-haired area on the belly

nervous system

nervous system phenotype ( J:230341 )

N • at E16.5, E18.5 and P0, no significant differences are observed in the number or distribution pattern of melanoblasts in the epidermis of vibrissae, back or abdominal skin relative to control mice