Phenotypes Associated with This Genotype

Genotype
MGI:6241342

• Allelic Composition: Smarca4^mos6/Smarca4⁺; Sox10^tm1Weg/Sox10⁺
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

pigmentation

belly spot ( J:241206 )

• adult double heterozygous mice exhibit more severe ventral white spotting than typically observed in single Sox10^tm1Weg heterozygotes

head spot ( J:241206 )

• adult double heterozygous mice exhibit a head spot

integument

belly spot ( J:241206 )

• adult double heterozygous mice exhibit more severe ventral white spotting than typically observed in single Sox10^tm1Weg heterozygotes

head spot ( J:241206 )

• adult double heterozygous mice exhibit a head spot

embryo

abnormal melanoblast morphology ( J:241206 )

• at E13.5, double heterozygous mice show a significant reduction of cranial melanoblast numbers relative to single Sox10^tm1Weg heterozygotes

nervous system

abnormal melanoblast morphology ( J:241206 )

• at E13.5, double heterozygous mice show a significant reduction of cranial melanoblast numbers relative to single Sox10^tm1Weg heterozygotes