Analysis Tools
pigmentation
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• 73.3% of mice exhibit mild but accelerated hair graying within 10 months after birth relative to control mice; the frequency of gray hairs is variable depending on the individual mouse
• hair graying is likely caused by incomplete maintenance of melanocyte stem cells
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• late anagen follicles exhibit LacZ+ dendritic and slightly pigmented melanocytes with large cell bodies in the bulge-subbulge area; in contrast, LacZ+ melanoblasts in the bulge area of control follicles are immature and small with minimal dendrites, typical features of melanocyte stem cells
• at 6 months of age, the frequency of hair follicles with large and dendritic melanocytes or pigmented melanocytes in the bulge area of anagen IV-VI follicles is significantly higher than that in control follicles
• some follicles show complete loss of Dct-lacZ+ cells in the bulge area, suggesting that melanocyte stem cells have prematurely differentiated and are eventually depleted from the stem cell niche
• melanocyte stem cells are lost in the bulge area of almost all follicles that produce white hair
• in contrast, the distribution of epidermal and dermal melanocytes in the pigmented junctional epithelium is normal
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• mice exhibit deposition of melanin pigment in the bulge area of midanagen hair follicles
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• melanin incontinence in the dermal papillae of hair follicles occurs more frequently than in control follicles
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• midanagen hair follicles begin to show ectopically pigmented melanocytes with dendritic morphologies starting from the second hair cycle
• ectopically differentiated melanocytes are preferentially seen in follicles that show pigmentation defects in the hair matrix
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integument
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• 73.3% of mice exhibit mild but accelerated hair graying within 10 months after birth relative to control mice; the frequency of gray hairs is variable depending on the individual mouse
• hair graying is likely caused by incomplete maintenance of melanocyte stem cells
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• late anagen follicles exhibit LacZ+ dendritic and slightly pigmented melanocytes with large cell bodies in the bulge-subbulge area; in contrast, LacZ+ melanoblasts in the bulge area of control follicles are immature and small with minimal dendrites, typical features of melanocyte stem cells
• at 6 months of age, the frequency of hair follicles with large and dendritic melanocytes or pigmented melanocytes in the bulge area of anagen IV-VI follicles is significantly higher than that in control follicles
• some follicles show complete loss of Dct-lacZ+ cells in the bulge area, suggesting that melanocyte stem cells have prematurely differentiated and are eventually depleted from the stem cell niche
• melanocyte stem cells are lost in the bulge area of almost all follicles that produce white hair
• in contrast, the distribution of epidermal and dermal melanocytes in the pigmented junctional epithelium is normal
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• mice exhibit deposition of melanin pigment in the bulge area of midanagen hair follicles
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• melanin incontinence in the dermal papillae of hair follicles occurs more frequently than in control follicles
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