Phenotypes Associated with This Genotype

Genotype
MGI:6236323

• Allelic Composition: Tg(ACTB-EGFP,-Kcnj8*G343D)9Nich/0; Tg(Myh11-icre/ERT2)1Soff/0
• Genetic Background: involves: C57BL/6 * CBA * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

hypotension ( J:202037 )

• systolic and diastolic blood pressures are lower 3 weeks following tamoxifen induction

• however, heart rate is not affected

abnormal vascular smooth muscle physiology ( J:202037 )

• in vascular smooth muscle cells (VSMC), potassium currents are higher than in control VSMCs under basal conditions and with the K(ATP) channel opener, pinacidil, indicating enhanced K(ATP) channel currents

decreased vasoconstriction ( J:202037 )

• contraction of mesenteric arteries in response to phenylephrine is shifted about 10-fold to higher phenylephrine concentration compared to control arteries , with an even greater relative shift in the presence of pinacidil, indicating reduced contractility of blood vessels

• however, following constriction by high phenylephrine concentration, subsequent K(ATP)-independent relaxation in response to sodium nitroprusside is not different

muscle

abnormal vascular smooth muscle physiology ( J:202037 )

• in vascular smooth muscle cells (VSMC), potassium currents are higher than in control VSMCs under basal conditions and with the K(ATP) channel opener, pinacidil, indicating enhanced K(ATP) channel currents

decreased vasoconstriction ( J:202037 )

• contraction of mesenteric arteries in response to phenylephrine is shifted about 10-fold to higher phenylephrine concentration compared to control arteries , with an even greater relative shift in the presence of pinacidil, indicating reduced contractility of blood vessels

• however, following constriction by high phenylephrine concentration, subsequent K(ATP)-independent relaxation in response to sodium nitroprusside is not different