Phenotypes Associated with This Genotype

Genotype
MGI:6236250

• Allelic Composition: Notch1^tm1Con/Notch1⁺
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

cardiovascular system phenotype ( J:187551 )

N • mice fed a hypercholesterolemic diet supplemented with vitamin D (HCVD), exhibit normal echocardiography measurements

calcified aortic valve cusp ( J:187551 )

• mice fed the HCVD diet exhibit a moderate level of aortic valve leaflet calcification

thick aortic valve cusps ( J:187551 )

• leaflets are thicker in mice fed control chow and diet does not have an effect on leaflet thickness

aortic valve inflammation ( J:187551 )

• mice exhibit increased aortic valve inflammation when fed the HCVD diet, showing increased macrophage infiltration in the leaflets

immune system

aortic valve inflammation ( J:187551 )

• mice exhibit increased aortic valve inflammation when fed the HCVD diet, showing increased macrophage infiltration in the leaflets