Phenotypes Associated with This Genotype

Genotype
MGI:6200801

• Allelic Composition: Bpifa1^tm1.2Jpst/Bpifa1^tm1.2Jpst
• Genetic Background: involves: BALB/cJ * C57BL/6 * C57BL/6J * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased susceptibility to Orthomyxoviridae infection ( J:265391 )

• when infected intranasally with Influenza A virus (IAV X-31), mice exhibit increased weight loss (12% at day 6 p.i. vs 5% in wild-type), at least 10-fold higher virus titres at all days tested, and faster penetration of virus in distal bronchioles and alveoli at day 1 p.i. (where not found in wild-type)

increased susceptibility to Orthomyxoviridae infection induced morbidity/mortality ( J:265391 )

• when infected intranasally with Influenza A virus (IAV X-31)

mortality/aging

increased susceptibility to Orthomyxoviridae infection induced morbidity/mortality ( J:265391 )

• when infected intranasally with Influenza A virus (IAV X-31)