Phenotypes Associated with This Genotype

Genotype
MGI:6199992

• Allelic Composition: Ebf1^m2Btlr/Ebf1^m2Btlr
• Genetic Background: C57BL/6J-Ebf1^m2Btlr

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

increased B-1a cell number ( J:265158 )

increased B-1b cell number ( J:265158 )

decreased B cell number ( J:265158 )

• of B cells, IgM+ B cells, and IgD+ B cells in the peripheral blood

decreased B-1 B cell number ( J:265158 )

decreased B-2 B cell number ( J:265158 )

increased T cell number ( J:265158 )

increased CD4-positive, alpha-beta T cell number ( J:265158 )

increased single-positive T cell number ( J:265158 )

decreased IgD level ( J:265158 )

decreased IgM level ( J:265158 )

• reduced T-independent antibody response to NP-Ficoll

increased IgM level ( J:265158 )

• reduced T-dependent antibody responses toalum-precipitated OVA

• reduced T-dependent antibody responses to recombinant Semliki Forest virus (rSFV)-encoded beta-galactosidase (rSFV-beta-gal)

immune system

increased B-1a cell number ( J:265158 )

increased B-1b cell number ( J:265158 )

decreased B cell number ( J:265158 )

• of B cells, IgM+ B cells, and IgD+ B cells in the peripheral blood

decreased B-1 B cell number ( J:265158 )

decreased B-2 B cell number ( J:265158 )

increased T cell number ( J:265158 )

increased CD4-positive, alpha-beta T cell number ( J:265158 )

increased single-positive T cell number ( J:265158 )

abnormal humoral immune response ( J:265158 )

• reduced T-dependent antibody responses toalum-precipitated OVA

• reduced T-dependent antibody responses to recombinant Semliki Forest virus (rSFV)-encoded beta-galactosidase (rSFV-beta-gal)

• reduced T-independent antibody response to NP-Ficoll

decreased IgD level ( J:265158 )

decreased IgM level ( J:265158 )

• reduced T-independent antibody response to NP-Ficoll

increased IgM level ( J:265158 )

• reduced T-dependent antibody responses toalum-precipitated OVA

• reduced T-dependent antibody responses to recombinant Semliki Forest virus (rSFV)-encoded beta-galactosidase (rSFV-beta-gal)

increased tumor necrosis factor secretion ( J:265158 )

• in response to TLR7 ligand, R848