Phenotypes Associated with This Genotype

Genotype
MGI:6199668

• Allelic Composition: Ahr^tm3.1Bra/Ahr^tm3.1Bra; Tg(Six3-cre)69Frty/0
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

increased retina apoptosis ( J:265123 )

• increased expression of proapoptotic protein Ddit3

• according to TUNEL assay

short photoreceptor outer segment ( J:265123 )

• thinner at age 18 months

photoreceptor outer segment degeneration ( J:265123 )

• thinner at age 18 months

retina photoreceptor degeneration ( J:265123 )

• reduced number of photoreceptor cells per row in outer nuclear layer (ONL) at age 18 months

retina outer nuclear layer degeneration ( J:265123 )

• reduced number of photoreceptor cells per row at age 18 months

retina degeneration ( J:265123 )

• reduced number of photoreceptor cells outer nuclear layer (ONL) per row at age 18 months

• thinner outer segment at age 18 months

• inner nuclear layer (INL) at age 18 months

abnormal rod electrophysiology ( J:265123 )

• decreased scotopic responses at age 12 months: around 30 % reduction in b-wave and around 15 % reduction in a-wave mean amplitude at 0 and 1 log cd.s/m² light intensity

nervous system

short photoreceptor outer segment ( J:265123 )

• thinner at age 18 months

photoreceptor outer segment degeneration ( J:265123 )

• thinner at age 18 months

retina photoreceptor degeneration ( J:265123 )

• reduced number of photoreceptor cells per row in outer nuclear layer (ONL) at age 18 months

cellular

increased retina apoptosis ( J:265123 )

• increased expression of proapoptotic protein Ddit3

• according to TUNEL assay