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Phenotypes Associated with This Genotype
Genotype
MGI:6198768
Allelic
Composition		 Eif2ak3tm1.2Drc/Eif2ak3tm1.2Drc
Ptentm1Hwu/Ptentm1Hwu
Tg(CAG-MYC,-GFP*)#Rugg/0
Tg(Pbsn-cre)4Prb/0
Genetic
Background		 involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6 * C57BL/6J * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Eif2ak3tm1.2Drc mutation (1 available); any Eif2ak3 mutation (51 available)
Ptentm1Hwu mutation (17 available); any Pten mutation (87 available)
Tg(CAG-MYC,-GFP*)#Rugg mutation (0 available)
Tg(Pbsn-cre)4Prb mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
decreased prostate gland tumor incidence ( J:261540 )
• mice show reduced prostate growth, with a decrease prostate cancer progression and cell proliferation compared to Ptentm1Hwu/Ptentm1Hwu Tg(Pbsn-cre)4Prb/0 Tg(CAG-MYC,-GFP)#Rugg/0 mice

neoplasm
decreased prostate gland tumor incidence ( J:261540 )
• mice show reduced prostate growth, with a decrease prostate cancer progression and cell proliferation compared to Ptentm1Hwu/Ptentm1Hwu Tg(Pbsn-cre)4Prb/0 Tg(CAG-MYC,-GFP)#Rugg/0 mice

reproductive system
decreased prostate gland tumor incidence ( J:261540 )
• mice show reduced prostate growth, with a decrease prostate cancer progression and cell proliferation compared to Ptentm1Hwu/Ptentm1Hwu Tg(Pbsn-cre)4Prb/0 Tg(CAG-MYC,-GFP)#Rugg/0 mice

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory