Phenotypes Associated with This Genotype

Genotype
MGI:6196149

• Allelic Composition: Krt14^{tm1.1(cre)Wbm}/Krt14⁺; Tg(KRT14-Snai1)1Efu/0; Trp53^tm1Brn/Trp53^tm1Brn
• Genetic Background: involves: 129P2/OlaHsd * CD-1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

increased sebaceous gland tumor incidence ( J:229072 )

• sebaceous gland carcinoma

integument

increased sebaceous gland tumor incidence ( J:229072 )

• sebaceous gland carcinoma

increased skin tumor incidence ( J:229072 )

• mice develop skin tumors more rapidly than single Tg(KRT14-Snai1)1Efu expressing mice, with a median latency of 176 days

• however, mice do not develop more tumors than Tg(KRT14-Snai1)1Efu mice alone

• tumors include basal cell carcinoma, squamous cell carcinoma, and sebaceous gland carcinoma and more aggressive carcinosarcomas characterized by the biphasic appearance of intermixed epithelial and mesenchymal elements

increased basal cell carcinoma incidence ( J:229072 )

increased skin squamous cell carcinoma incidence ( J:229072 )

neoplasm

increased sebaceous gland tumor incidence ( J:229072 )

• sebaceous gland carcinoma

increased skin tumor incidence ( J:229072 )

• mice develop skin tumors more rapidly than single Tg(KRT14-Snai1)1Efu expressing mice, with a median latency of 176 days

• however, mice do not develop more tumors than Tg(KRT14-Snai1)1Efu mice alone

• tumors include basal cell carcinoma, squamous cell carcinoma, and sebaceous gland carcinoma and more aggressive carcinosarcomas characterized by the biphasic appearance of intermixed epithelial and mesenchymal elements

increased basal cell carcinoma incidence ( J:229072 )

increased skin squamous cell carcinoma incidence ( J:229072 )