Phenotypes Associated with This Genotype

Genotype
MGI:6195768

• Allelic Composition: Bcas3^tm1Msin/Bcas3^tm1Msin; Tg(Tek-cre)1Ywa/0
• Genetic Background: involves: C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:262744 )

• fewer than expected mice are present at E9.5 and only 1 at E13.5 (no mice are present postnatally)

cardiovascular system

abnormal capillary morphology ( J:262744 )

• in head and heart vasculature

abnormal intersomitic vessel morphology ( J:262744 )

• discontinuous and improperly patterned

abnormal vascular development ( J:262744 )

• abnormal head and heart vasculature at E10.5 that is not as severe as in constitutive knock-outs

abnormal dorsal aorta morphology ( J:262744 )

• discontinuous and improperly patterned

abnormal vascular branching morphogenesis ( J:262744 )

• impaired branching in head and heart vasculature

decreased angiogenesis ( J:262744 )

• reduced sprouting in head and heart vasculature and of intersomitic vessels

abnormal endocardium morphology ( J:262744 )

• reduced development

small heart ( J:262744 )

• collapsed, small heart chambers

embryo

abnormal placenta morphology ( J:262744 )

• fetal vessels fail to invade into the developing placenta at E11.5

• however, fetal vessel invasion at E10.5 is normal

small placenta ( J:262744 )

• reduced thickness at E10.5 and E11.5

abnormal visceral yolk sac morphology ( J:262744 )

• reduced branching from major vessels in the yolk sac with vessel fusion and loss of branch hierarchy at E10.5 and E11.5

growth/size/body

abnormal head morphology ( J:262744 )

• at E10.5